Taking into account that patients with inflammation may develop different diseases at the same time, clinical testing may not always detect a clear cause of the inflammation, which will lead to delays in treatment and the abuse of antibiotics. Moreover, it is predicted that by 2050, antibiotic-resistant infections will become the leading cause of death in humans. Bacterial infections have become one of the highest causes of morbidity and mortality in the world, especially in developing countries. However, currently, in many countries, the overuse of antibiotics has led to the appearance of drug-resistant bacteria, which greatly restrict the effect of the use of antibiotics. By the 20th century, the treatment of infections had been greatly improved due to the discovery of antibiotics. In the 18th and 19th centuries, public health has developed significantly. SPECT image of Tc-CN5NF showed that there was a clear accumulation in the infection site, suggesting that it could be a potential bacterial infection imaging radiotracer. In addition, Tc-CN5NF had higher abscess/blood and abscess/muscle ratios.

Compared with Tc-CN4NF, biodistribution studies of Tc-CN5NF showed a higher uptake in bacteria-infected tissues than in turpentine-induced abscesses, indicating that Tc-CN5NF could distinguish bacterial infection from sterile inflammation. The bacterial binding assay indicated that Tc-CN4NF and Tc-CN5NF were specific to bacteria.

These compounds were produced in high radiolabeling yields and showed hydrophilicity and good stability in vitro. To develop potential technetium-99m single-photon emission computed tomography (SPECT) imaging agents for bacterial infection imaging, the novel norfloxacin isonitrile derivatives CN4NF and CN5NF were synthesized and radiolabeled with a + core to obtain Tc-CN4NF and Tc-CN5NF.

Microsoft safety scanner infected files